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HDAC6-Dependent Functions in Tumor Cells: Crossroad with the MAPK Pathways

Joshua Haakenson1, Jheng-Yu Wu1, Shengyan Xiang1

  • 1University of South Florida, Tampa, FL.

Critical Reviews in Oncogenesis
|March 10, 2015
PubMed

Insights

Histone deacetylase 6 (HDAC6) is a potential cancer therapeutic target. This review highlights HDAC6

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Histone deacetylase 6 (HDAC6) is implicated in cancer progression.
  • HDAC6 regulates critical cellular processes including migration, transformation, and DNA damage response.
  • HDAC6 is increasingly recognized as a viable therapeutic target in oncology.

Purpose of the Study:

  • To review the intricate relationship between HDAC6 and mitogen-activated protein kinase (MAPK) pathways.
  • To elucidate the regulatory mechanisms linking HDAC6 and MAPK signaling.
  • To emphasize the specific interactions between HDAC6 and the ERK-MAPK cascade.

Main Methods:

  • Literature review of studies investigating HDAC6 and MAPK pathways.
  • Analysis of research on HDAC6 regulation by signaling cascades like EGF-EGFR-Ras-Raf-MEK-ERK.
  • Examination of evidence for HDAC6's modulation of EGFR and Ras functions.

Main Results:

  • HDAC6 plays a significant role in cancer-related cellular functions.
  • HDAC6 activity is regulated by the EGF-EGFR-Ras-Raf-MEK-ERK signaling pathway.
  • HDAC6 reciprocally influences the functions of EGFR and Ras proteins.

Conclusions:

  • HDAC6 is a key player in cancer biology, interacting with MAPK pathways.
  • The interplay between HDAC6 and ERK-MAPK signaling is crucial for understanding cancer mechanisms.
  • Targeting HDAC6 offers a promising strategy for cancer therapy.

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