Regenerative medicine for Parkinson's disease
Takao Yasuhara1, Masahiro Kameda, Takashi Agari
1Department of Neurological Surgery, Okayama University Graduate School of Medicine.
Neurologia Medico-Chirurgica
|March 10, 2015
Summary
Regenerative medicine offers hope for Parkinson's disease (PD) beyond current treatments. Advances in biotechnology, including stem cell therapy, aim for true neurorestoration in PD patients.
Area of Science:
- Neuroscience
- Biotechnology
- Regenerative Medicine
Background:
- Current Parkinson's disease (PD) treatments like L-DOPA and deep brain stimulation manage symptoms but do not halt disease progression.
- True neurorestoration remains a significant unmet need for Parkinson's disease patients.
- Regenerative medicine holds promise for developing novel therapeutic strategies for PD.
Purpose of the Study:
- To review the historical development of regenerative medicine for Parkinson's disease (PD).
- To examine current cell and gene therapy approaches for PD.
- To discuss future directions for regenerative medicine in PD treatment.
Main Methods:
- Historical review of regenerative medicine strategies for PD.
- Focus on fetal nigral cell transplantation and glial cell line-derived neurotrophic factor (GDNF) infusion.
- Review of current cell therapy and gene therapy research for PD.
Main Results:
- Fetal nigral cell transplantation and GDNF infusion represent key historical milestones in PD regenerative medicine.
- Current research is exploring advanced cell therapies and gene therapies for PD.
- Induced pluripotent stem cells are a key biotechnological advancement in PD regenerative medicine.
Conclusions:
- Regenerative medicine, particularly stem cell therapy, is crucial for achieving neurorestoration in Parkinson's disease.
- Continued advancements in biotechnology are vital for the future of PD regenerative medicine.
- Future research should focus on translating current regenerative approaches into effective PD treatments.
More Related Videos
Related Concept Videos
Parkinson's Disease: Treatment
1.4K
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
1.4K
Parkinson's Disease: Overview
2.5K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
2.5K
EPS and iPS Cells in Disease Research
3.5K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K
Neural Regulation
45.2K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
45.2K
iPS Cell Differentiation
3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Stem Cell Therapy for Tissue Regeneration
5.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
5.0K


