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Articles linked to this work by shared authors, journal, and citation graph.

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[Fecal microbiota transplantation in recurrent Clostridium difficile infections. Framework and pharmaceutical preparation aspects].

Annales pharmaceutiques francaises·2015
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[Fecal microbiota transplantation: review].

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[Why could gut microbiota become a medication?].

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Faecal microbiota transplantation: a sui generis biological drug, not a tissue.

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Related Experiment Video

Updated: Apr 16, 2026

Murine Fecal Isolation and Microbiota Transplantation
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Faecal microbiota transplantation: Key points to consider.

P Bourlioux1,

  • 1Académie de pharmacie, 4, avenue de l'Observatoire, 75270 Paris cedex 06, France; Microbiologie, faculté de pharmacie, université Paris-Sud, rue J.B.-Clément, 92390 Chatenay-Malabry cedex, France.

Annales Pharmaceutiques Francaises
|March 10, 2015
PubMed
Summary

Faecal microbiota transplantation (FMT) is a successful treatment for recurrent Clostridium difficile infection. Further research is needed to understand FMT

Keywords:
Faecal microbiota transplantationInfection à Clostridium difficileRecurrent Clostridium difficile infectionsTransfert de microbiote fécal

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Immunology

Background:

  • Faecal microbiota transplantation (FMT) is the gold standard for recurrent Clostridium difficile infection (CDI) unresponsive to antibiotics.
  • FMT restores intestinal flora but its mechanism of action is not fully understood.
  • The complex and variable nature of FMT poses challenges for standardization and quality assessment.

Purpose of the Study:

  • To highlight the need for further biomedical research into FMT.
  • To develop protocols for elucidating FMT's mechanism of action.
  • To support the production of safe and effective FMT products.

Main Methods:

  • Review of current understanding of FMT efficacy and limitations.
  • Discussion of challenges in characterizing and standardizing FMT preparations.
  • Emphasis on the necessity of rigorous donor selection and microbiological control.

Main Results:

  • FMT effectively eradicates C. difficile and aids in restoring gut microbiota.
  • Current limitations in characterizing FMT hinder its classification as a conventional biologic drug.
  • Existing manufacturing and laboratory practices require international consensus for FMT.

Conclusions:

  • Biomedical research is crucial for understanding FMT's mechanism of action.
  • Standardized protocols are needed for the safe and efficacious production of FMT.
  • Further experience and consensus are required to establish international standards for FMT.