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Cancer stratification by molecular imaging.

Justus Weber1, Uwe Haberkorn2, Walter Mier3

  • 1Heidelberg University Hospital, Department of Nuclear Medicine, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. ju.weber.ma@gmx.de.

International Journal of Molecular Sciences
|March 10, 2015
PubMed
Summary

Molecular imaging enables precise cancer stratification by identifying specific molecular targets. This approach combines biomarkers and signal sources for simultaneous cancer localization and stratification, improving targeted therapy selection.

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Area of Science:

  • Oncology
  • Radiology
  • Molecular Biology

Background:

  • Traditional chemotherapy lacks specificity, leading to targeted anticancer agents.
  • Targeted therapies require detailed tumor characteristic information for patient subgroup applicability.
  • Current cancer stratification methods include gene expression, proteomics, immunohistochemistry, and molecular imaging.

Purpose of the Study:

  • To review methods, targets, and agents in molecular imaging for cancer stratification.
  • To highlight the role of radiotracers in identifying cancer-associated markers.
  • To outline the application of molecular imaging in precise cancer localization and stratification.

Main Methods:

  • Molecular imaging utilizes selective biomarkers and signal sources for target localization.
  • Analysis of altered receptor expression (e.g., somatostatin, folate, Her2).
  • Detection of transporter expression (e.g., glucose, amino acid, hNIS) and cell-specific proteins (e.g., PSMA, integrins, CD20).

Main Results:

  • Molecular imaging allows simultaneous cancer stratification and localization.
  • Identified targets include various receptors, transporters, and cell-specific proteins.
  • Radiotracers are crucial for detecting altered expression patterns of cancer markers.

Conclusions:

  • Molecular imaging is a key tool for precise cancer stratification and localization.
  • It facilitates the exploitation of targeted anticancer agents by identifying specific patient subgroups.
  • The review emphasizes radiotracers for identifying cancer-associated markers and guiding treatment decisions.