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Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

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Updated: May 22, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Internal Radiation Therapy.

Uwe Haberkorn1,2,3, Clemens Kratochwil1, Eduards Mamlins4

  • 1Department of Nuclear Medicine, University Hospital Heidelberg, Heidelberg, Germany.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|May 21, 2026
PubMed
Summary
This summary is machine-generated.

Targeted cancer therapies use carrier molecules to deliver drugs or radiation directly to tumors, enhancing treatment effectiveness and reducing side effects. Examples include DOTATOC for somatostatin receptors and small molecules for prostate-specific membrane antigen.

Keywords:
DOTATOCPSMAPeptidesSmall moleculesEndoradiotherapy

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Area of Science:

  • Oncology
  • Radiochemistry
  • Molecular Biology

Background:

  • Targeted therapies aim to improve antitumor treatment efficacy while minimizing side effects.
  • Carrier molecules are essential for delivering therapeutic agents specifically to tumor sites.
  • These carriers can be antibodies, peptides, or small molecules that bind to tumor-specific targets.

Purpose of the Study:

  • To explore the application of targeted therapies using carrier molecules for enhanced antitumor treatment.
  • To highlight the role of specific binding molecules in delivering chemotherapeutics or radioactive isotopes.
  • To provide examples of successful targeted agents in clinical use.

Main Methods:

  • Utilizing carrier molecules (antibodies, peptides, small molecules) for targeted drug or radioisotope delivery.
  • Identifying and targeting tumor-specific antigens or overexpressed receptors.
  • Employing tracers like DOTATOC for somatostatin receptor targeting.

Main Results:

  • Carrier molecules demonstrate specific binding to target structures on tumor cells.
  • Targeted delivery enhances the efficiency of antitumor treatment.
  • Reduced systemic exposure leads to decreased side effects.
  • Successful examples include DOTATOC and small molecule inhibitors for PSMA.

Conclusions:

  • Targeted therapies with carrier molecules offer a promising strategy for effective cancer treatment.
  • Specific molecular targeting is key to improving therapeutic outcomes and patient safety.
  • Endoradiotherapy, exemplified by DOTATOC and PSMA inhibitors, represents a significant advancement in oncology.