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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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Updated: May 22, 2026

Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling
10:07

Positron Emission Tomography Imaging of Cell Trafficking: A Method of Cell Radiolabeling

Published on: October 27, 2023

Clinical Applications of Theranostics.

Jonathan Kuten1, Lisa Bodei1, Jason S Lewis2,3

  • 1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progres Dans Les Recherches Sur Le Cancer
|May 21, 2026
PubMed
Summary
This summary is machine-generated.

Radiotheranostics combines imaging and targeted radionuclide therapy for personalized cancer treatment. This approach visualizes and treats tumors simultaneously, improving outcomes for various cancers.

Keywords:
Alpha and beta emittersMolecular imagingPET/CTPrecision oncologyRadiolabeled agentsRadiopharmaceutical therapySPECT/CTTherapeutic isotopesTumor-specific targetingRadiotheranostics

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Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Radiotheranostics merges molecular imaging and targeted radionuclide therapy for personalized cancer treatment.
  • It utilizes radiolabeled agents that bind to tumor-specific targets, enabling visualization and treatment.
  • The principle of "treat what you see" guides the integration of diagnostic and therapeutic applications.

Purpose of the Study:

  • To provide an overview of the radiotheranostics field.
  • To highlight its role in personalized cancer care.
  • To discuss its evolution, applications, and future challenges.

Main Methods:

  • Pairing targeting molecules (peptides, small molecules, antibodies) with diagnostic or therapeutic radioisotopes.
  • Utilizing imaging modalities like positron emission tomography (PET) and single-photon emission computed tomography (SPECT) for visualization.
  • Administering beta and alpha emitters for targeted radionuclide therapy.

Main Results:

  • Radiotheranostics has demonstrated improved outcomes in neuroendocrine tumors and prostate cancer.
  • It offers a systemic alternative to external beam radiotherapy with personalized dosimetry.
  • Real-time monitoring and individualized treatment are enabled by this approach.

Conclusions:

  • Radiotheranostics is a rapidly advancing field with emerging applications in oncology.
  • While generally safe, careful management of potential toxicities is necessary.
  • Overcoming challenges in isotope supply, infrastructure, and training is crucial for broader clinical integration and its role in precision cancer care.