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Korean Medication Algorithm Project for Bipolar Disorder: third revision.

Young Sup Woo1, Jung Goo Lee2, Jong-Hyun Jeong1

  • 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, South Korea.

Neuropsychiatric Disease and Treatment
|March 10, 2015
PubMed
Summary
This summary is machine-generated.

This study revises bipolar disorder treatment guidelines, showing increased expert preference for atypical antipsychotics (AAP) and lamotrigine (LTG) in various phases and populations. Guidelines now emphasize AAP combinations for acute mania and depression.

Keywords:
expert consensuspharmacological treatmenttreatment guideline

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Guidelines

Background:

  • Bipolar disorder requires updated treatment guidelines.
  • Previous Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP) guidelines need revision.
  • Expert consensus is crucial for refining treatment algorithms.

Purpose of the Study:

  • To update the KMAP-BP guidelines for bipolar disorder treatment.
  • To establish expert consensus on pharmacological strategies for different bipolar disorder phases.
  • To address special populations including children, adolescents, and geriatric patients.

Main Methods:

  • A 56-item questionnaire surveyed expert opinions.
  • 110 Korean psychiatrists and 38 child/adolescent psychiatrists were invited.
  • 64 general psychiatrists and 23 child/adolescent psychiatrists responded.

Main Results:

  • Combination therapy (mood stabilizer + atypical antipsychotic) is preferred for acute mania and moderate/severe depression.
  • Monotherapy with mood stabilizers or atypical antipsychotics is recommended for acute mild depression.
  • Lamotrigine and atypical antipsychotics show increased preference in maintenance and specific populations.

Conclusions:

  • The KMAP-BP 2014 guidelines reflect a shift in expert preference towards atypical antipsychotics and lamotrigine.
  • Increased use of atypical antipsychotics is noted for acute mania, depression, and maintenance.
  • The study's findings are based on expert consensus, with a limitation of not being solely evidence-based.