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Updated: Apr 16, 2026
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Determining need for treatment in residual pituitary adenomas
G M Davies1, C Huang, J M Sheehan
1Department of Neurosurgery, Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center, Hershey, PA, USA - jsheehan@psu.edu.
Aim:
The optimal management of residual pituitary adenoma after resection is not clearly defined, with some authors proposing early radiosurgery or radiotherapy for patients with evidence of residual tumor on postoperative imaging and others recommending observation alone. This retrospective study seeks to determine the most appropriate treatment for patients with evidence of residual tumor on postoperative MRI.
Methods:
Forty-one consecutive patients who underwent transsphenoidal resection of pituitary adenomas between 2002 and 2005 and were followed radiographically and clinically for a mean of 4.4 years were analyzed.
Results:
Despite an official interpretation by a board-certified neuroradiologist suggesting the presence of residual tumor postoperatively in twenty-four out of forty-one patients, only four patients (16.7%) required additional intervention during the follow-up period. None of the patients received perioperative radiotherapy.
Conclusion:
This suggests that aggressive management of radiographically suspected residual tumor may not be indicated and that observation with serial imaging may be sufficient in the management of patients with residual tumor.
