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Related Concept Videos

Fractures: Bone Repair01:27

Fractures: Bone Repair

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Changes in the Appendicular Skeleton with Age01:09

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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Related Experiment Video

Updated: Apr 16, 2026

Evaluating the Function of the Foot Core System in the Elderly
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[Ankle fractures in the elderly patient].

Xavier Crevoisier, Rayan Baalbaki, Tiago Dos Santos

    Revue Medicale Suisse
    |March 11, 2015
    PubMed
    Summary

    Elderly patients with ankle fractures can benefit from augmented internal fixation using bone cement. This technique allows for early full weight bearing, improving outcomes for patients with poor bone quality.

    Area of Science:

    • Orthopedic surgery
    • Geriatric medicine
    • Biomaterials science

    Context:

    • Ankle fractures in adults typically require open reduction internal fixation (ORIF).
    • Elderly patients present unique challenges due to osteoporosis and comorbidities, compromising traditional ORIF.
    • Poor bone quality in the elderly can lead to fixation failure, wound complications, and infection.

    Purpose:

    • To explore augmented internal fixation techniques for ankle fractures in elderly patients.
    • To address the challenges posed by osteoporotic bone in achieving secure screw purchase.
    • To enable early, unrestricted weight-bearing in a fragile patient population.

    Summary:

    • Augmented internal fixation using metal and bone cement offers a solution for ankle fractures in elderly patients with osteoporosis.

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  • This approach overcomes the limitations of traditional internal fixation in osteopenic bone.
  • It facilitates early full weight-bearing in a removable brace, mitigating risks associated with prolonged non-weight bearing.

    • Impact:

    • Improved functional recovery for elderly patients with ankle fractures.
    • Reduced risk of complications associated with poor screw purchase and prolonged immobilization.
    • Enhanced treatment options for a vulnerable geriatric population facing orthopedic injuries.