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Potential of biofluid components to modify silver nanoparticle toxicity.

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Biofluid components like bile acids can alter silver nanoparticle (AgNP) toxicity in the gut. This interaction depends on the specific bile acid and cell type, impacting AgNP risk assessment.

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Area of Science:

  • Nanotoxicology
  • Gastrointestinal Toxicology
  • Biochemistry

Background:

  • Realistic exposure scenarios are crucial for assessing silver nanoparticle (AgNP) toxicity.
  • Biofluid components, such as bile acids, may influence AgNP interactions within the gastrointestinal tract.
  • Understanding these interactions is vital for accurate risk assessment of nanomaterials.

Purpose of the Study:

  • To investigate the effect of specific bile acids (cholic acid, deoxycholic acid, ursodeoxycholic acid) on AgNP toxicity.
  • To explore the interaction between AgNPs and biofluid components using relevant cell lines (HepG-2, Hep2).
  • To determine if bile acids modify the cytotoxic effects of AgNPs.

Main Methods:

  • Physicochemical characterization of AgNPs.
  • Cytotoxicity assays on HepG-2 (liver) and Hep2 (epithelial) cell lines.
  • Assessment of reactive oxygen species (ROS) induction in the presence of bile acids and AgNPs.

Main Results:

  • Bile acids did not alter the physicochemical properties of AgNPs.
  • Cholic acid and deoxycholic acid increased AgNP-induced reactive oxygen species in both cell lines.
  • Ursodeoxycholic acid modified AgNP toxicity in Hep2 cells but not in HepG-2 cells.

Conclusions:

  • Biofluid components, specifically bile acids, can modulate AgNP toxicity.
  • The extent of toxicity modification is dependent on the type of bile acid and the cellular location.
  • These findings highlight the importance of considering in vivo conditions for accurate AgNP risk assessment.