Synthesis and antimicrobial activity of novel benzoxazine sulfonamide derivatives
Saidulu Konda1, Srujana Raparthi1, K Bhaskar1
1Organic Chemistry Division-II (CPC), CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, A.P., India.
Abstract:
A new series of benzoxazine-6-sulfonamide derivatives were synthesized in excellent yields and the resulting compounds were evaluated for their antimicrobial activities. All the synthesized compounds were assessed for their antibacterial and antifungal activities. Among them 1a, 1b, 1c, 1e, 1h, 2c, 2d, 2e, 2g, 2h, 2i, 2j, 2k and 2l showed low inhibitory concentration (MIC of 31.25 and 62.5 μg/mL) against Gram-positive bacteria, Gram-negative bacteria and fungi, which are comparable to the inhibitory effect of standard drugs.
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