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Author Spotlight: Advancing Protein Glycosylation Research Using a Fully Automated System
Published on: June 28, 2024
Small lectin ligands as a basis for applications in glycoscience and glycomedicine
Paul V Murphy1,2,3, Ashis Dhara1,2, Liam S Fitzgerald1,2,3
1School of Biological and Chemical Sciences, Galway, H91TK33, Ireland. paul.v.murphy@universityofgalway.ie.
Abstract:
Glycan recognition by lectins mediates important biological events. This Tutorial Review aims to introduce lectin-ligand interactions and show how these molecular recognition events inspire innovations such as: (i) glycomimetic ligands; (ii) multivalent ligand agonists/antagonists; (iii) ligands for precision delivery of therapies to cells, where therapies include vaccines, siRNA and LYTACs (iv) development of diagnostics. A small number of case studies are selected to demonstrate principles for development of new ligands for applications inspired by knowledge of natural glycan ligand structure and function.
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