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Infant pulmonary function testing in chronic pneumonitis of infancy due to surfactant protein C mutation

Avigdor Hevroni1, Aliza Goldman1, Chaim Springer1

  • 1Institute of Pulmonology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.

Pediatric Pulmonology
|March 11, 2015
PubMed

Insights

Infant pulmonary function testing (iPFT) aids in diagnosing and managing chronic lung diseases in infants. Serial iPFT proved safe and effective for guiding treatment decisions in infants with chronic pneumonitis of infancy.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Neonatology

Background:

  • Pulmonary function testing (PFT) is crucial for adult interstitial lung disease (ILD) management.
  • Data on PFT utility in infants with suspected ILD is limited.

Observation:

  • This paper details the use of infant pulmonary function testing (iPFT) in two infants.
  • Both infants had biopsy-confirmed chronic pneumonitis of infancy due to surfactant protein C mutation.

Findings:

  • Serial iPFT was safely and effectively utilized for diagnostic and follow-up decision-making.
  • iPFT provided valuable insights into the respiratory status of these infants.

Implications:

  • Infant pulmonary function testing can be a valuable tool in managing pediatric lung diseases.
  • This study supports the integration of iPFT into the clinical workup for suspected infant lung conditions.

Keywords:
child interstitial lung disease (chILD)chronic pneumonitis of infancy (CPI)diffuse lung disease (DLD)infant pulmonary function testing (iPFT)surfactant protein C deficiency (SFTPC)

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