Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Inter-tissue relationships of gene expression in liver, muscle and adipose tissue of children with end-stage chronic liver disease.

Journal of pediatric gastroenterology and nutrition·2026

Same author

Determinants of hepatic enzyme elevations following onasemnogene abeparvovec: Results from a unified immunomodulation protocol.

Journal of neuromuscular diseases·2026

Same author

Sudden Acute Liver Failure in Citrullinemia Type 1: An Argument for Earlier Liver Transplantation?

The Journal of pediatrics·2026

Same author

RGD-modified alginate enhances viability, metabolic reprogramming, and cytokine secretion profiles in encapsulated mesenchymal stromal cells.

Scientific reports·2026

Same author

Cryopreservation of hepatocytes: Impact of long-term storage and organ donor factors on cell quality for clinical applications.

Cell transplantation·2026

Same author

Paediatric diabetic ketoacidosis-associated acute liver failure in the post-COVID era: A case series.

Journal of pediatric gastroenterology and nutrition·2026

Same journal

Corrigendum to "Nuances in ATP7B Genetic Testing and Interpretation in India" [J Clin Exp Hepatol 16 (1) (2026) 103205].

Journal of clinical and experimental hepatology·2026

Same journal

Hepatic Melioidosis: A State-of-the-Art Review.

Journal of clinical and experimental hepatology·2026

Same journal

Overlap Syndromes and Associated Immunoglobulin-G4-Related Liver Diseases.

Journal of clinical and experimental hepatology·2026

Same journal

Redefinition of Fatty Liver Disease: Stigma or Fatphobia?

Journal of clinical and experimental hepatology·2026

Same journal

Relative Adrenal Insufficiency in Decompensated Cirrhosis With Hyponatremia: Disease Severity Marker or Therapeutic Target?

Journal of clinical and experimental hepatology·2026

Same journal

Liver Transplant Outcomes in Patients With Transjugular Intrahepatic Portosystemic Shunt: A Retrospective Cohort Study With Propensity Score Analysis.

Journal of clinical and experimental hepatology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 16, 2026

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Published on: February 10, 2018

Hepatocyte transplantation.

Ragai R Mitry¹, Robin D Hughes¹, Anil Dhawan¹

¹Institute of Liver Studies, King's College London School of Medicine at King's College Hospital, London, UK.

Journal of Clinical and Experimental Hepatology

|March 11, 2015

Summary

This summary is machine-generated.

Hepatocyte transplantation (HTx) shows promise for liver diseases, with over 80 patients successfully treated. Challenges like cell availability and engraftment need further research for wider clinical use.

Keywords:

ALF, acute liver failure Acute liver failure ApoB, apolipoprotein B EGTA, ethylene glycol-bis(2-aminoethylether)-N,N,N',N'-tetra-acetic acid FVII, factor VII deficiency GMP, good manufacturing practice HAS, human serum albumin HC, hepatocytes HTx, hepatocyte transplantation LDL, low density lipoprotein LTx, liver transplantation MRI, magnetic resonance imaging OTC, ornithine transcarbamylase hepatocyte transplantation liver disease stem cell transplantation

More Related Videos

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

Published on: November 4, 2018

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

Related Experiment Videos

Last Updated: Apr 16, 2026

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Published on: February 10, 2018

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

Lentiviral Vector-mediated Gene Therapy of Hepatocytes Ex Vivo for Autologous Transplantation in Swine

Published on: November 4, 2018

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Generation of a Humanized Mouse Liver Using Human Hepatic Stem Cells

Published on: August 29, 2016

Area of Science:

Hepatology
Transplantation Medicine
Regenerative Medicine

Background:

Hepatocyte transplantation (HTx) is an emerging therapy for metabolic liver disorders and acute liver failure.
Over 80 patients worldwide have undergone HTx, demonstrating procedural feasibility and safety in the short to medium term.

Purpose of the Study:

To review the current status and challenges of hepatocyte transplantation.
To identify key limiting factors hindering the broader application of HTx.

Main Methods:

Literature review of studies on hepatocyte transplantation.
Analysis of reported patient outcomes and identified challenges.

Main Results:

HTx has demonstrated feasibility and short- to medium-term success in a limited patient cohort.
Key limitations include the availability of high-quality hepatocytes and issues with cell engraftment, survival, and function.

Conclusions:

While HTx is a viable option for specific liver conditions, significant hurdles remain.
Further research into alternative cell sources (e.g., stem cells) and improving cell engraftment and function is crucial for advancing HTx as an alternative to liver transplantation.