[Beta1- and beta2-adrenergic effects on thrombocytopoiesis in rats]

The influence of beta 1- and beta 2-adrenergic agent injections to rats during 3 days, on the main parameters of thrombocytopoiesis: platelet number and per cent of build up 75seleno-methionine in newly-formed platelets of rats has been studied. It is established that beta 1-adreno-stimulation with dobutamine (DB) increases both the number of platelets and the per cent of build up isotope. Practolol (PC), a beta 1-adrenergic blocking agent, used separately, and combined application of PC + DB lowered significantly the parameters studied. Salbutamol stimulation of beta 2-adrenergic receptors induced an insignificant rise in the thrombocytopoiesis parameters. beta 1-adreno-stimulation with DB results in activation, while beta 1-adrenoblocking with PC--in suppression of thrombocytopoiesis. Pretreatment with PC prevents DB stimulating effect on thrombocytopoiesis, thus evidencing the beta 1-adrenoceptor dependence on the process.