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Updated: Apr 16, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
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Epstein-barr virus-related hemophagocytic lymphohistiocytosis: hematologic emergency in the critical care setting

Neda Hashemi-Sadraei1, Pimprapa Vejpongsa1, Muhamed Baljevic2

  • 1Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Case Reports in Hematology
|March 11, 2015
PubMed

Hemophagocytic lymphohistiocytosis (HLH) is a rare and potential life-threatening clinical syndrome that results from uncontrolled activation of the immune system. Secondary HLH, more commonly observed in adult patients, is seen in the context of underlying triggering conditions. Epstein-Barr virus (EBV) has been recognized as the leading infectious cause and is associated with a poor outcome. As clinical and laboratory features of HLH could overlap with septic shock syndrome in most patients, the diagnosis of HLH, especially in adults, is the most challenging aspect of the disease that results in delayed recognition and treatment of rapidly progressive multiorgan system failure. We report a case of Hemophagocytic lymphohistiocytosis in a patient who presented with signs of septic shock syndrome and we review the literature on the topic.

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