Related Experiment Videos
Linkage of the mouse LDL receptor gene on chromosome 9
S L Frank1, B A Taylor, A J Lusis
1Department of Microbiology, University of California, Los Angeles 90024.
Genomics
|October 1, 1989
Abstract:
We identified restriction fragment length variants of the mouse low-density lipoprotein receptor gene and used these to map the gene, designated Ldlr, to the proximal region of chromosome 9. An interspecific backcross between strains MEV and CAST/Ei yielded the following gene order and distances in centimorgans: Ldlr-18.8 +/- 5.6-Apoa-4-7.3 +/- 3.5-Mpi-1-10.2 +/- 3.9-Emv-3 or dilute. Analysis of recombinant inbred strains also indicated that Ldlr is tightly linked to a previously unmapped retroviral marker, Xmmv-67.