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Synergizing Antegrade Endoscopic with Bridging Vein Harvesting for Improvement of Great Saphenous Vein Graft Quality from the Lower Leg
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The relationship between vitamin D levels and saphenous vein graft patency

Fatih Sen1, Samet Yilmaz, Kevser G Balci

  • 1aCardiology Clinic, Turkey Yuksek Ihtisas Education and Research Hospital, Ankara bCardiology Clinic, Adana Numune Education and Research Hospital, Adana, Turkey.

Coronary Artery Disease
|March 11, 2015
PubMed

Insights

Lower vitamin D levels are linked to saphenous vein graft (SVG) disease after coronary artery bypass grafting. Maintaining adequate vitamin D may improve SVG patency in cardiovascular disease patients.

Area of Science:

  • Cardiovascular Medicine
  • Nutritional Science
  • Vascular Surgery

Background:

  • Vitamin D deficiency is increasingly associated with cardiovascular diseases.
  • Coronary artery bypass grafting (CABG) using saphenous vein grafts (SVGs) has suboptimal long-term patency rates.
  • Understanding factors influencing SVG disease is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the association between vitamin D levels and the development of disease in SVGs.
  • To identify potential risk factors for SVG disease in patients undergoing CABG.

Main Methods:

  • A cohort of 180 patients who underwent primary CABG with at least one SVG and subsequent angiography were analyzed.
  • Patients were categorized into two groups: those with SVG disease (n=100) and those with patent SVGs (n=80).
  • Vitamin D levels, C-reactive protein, and other clinical factors were assessed and compared between groups.

Main Results:

  • Patients with patent SVGs had significantly higher vitamin D levels compared to those with SVG disease (36.2±10.7 vs. 21.1±10.4, P<0.001).
  • Higher C-reactive protein levels were observed in the SVG disease group (P=0.001).
  • Multivariate analysis identified current smoking, diabetes mellitus, target artery diameter <1.5 mm, bypass duration, and lower vitamin D levels as independent predictors of SVG disease.

Conclusions:

  • Lower serum vitamin D levels are significantly associated with the presence of SVG disease.
  • These findings suggest a potential role for vitamin D in maintaining SVG patency post-CABG.
  • Further research is warranted to explore vitamin D supplementation as a strategy to improve SVG outcomes.
Abstract

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