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Updated: Jun 21, 2026
Engineering Molecular Recognition with Bio-mimetic Polymers on Single Walled Carbon Nanotubes
Published on: January 10, 2017
Highly Selective Near-Infrared Nanosensors for Dopamine Detection: Leveraging the Phase-Engineered ssDNA-SWCNT
Ramazan Bayat1,2, Muhammed Bekmezci1,2, Damla Ikballi1
1Sen Research Group, Department of Biochemistry, Dumlupinar University, Kutahya, 43000, Türkiye.
Abstract:
Single-walled carbon nanotubes (SWCNTs) that emit fluorescence in the near-infrared region (NIR) enable the identification of certain molecules as a result of surface modification. In this study, a selective sensor system against dopamine, a neurotransmitter, was developed by wrapping a Guanine-Thymine-Adenine (GTA)20-repeat single-stranded DNA structure around SWCNT. Sensor analysis fluorescence measurements in the NIR region were performed using a customized microscope system. The fluorescence activity of the developed (GTA)20-SWCNT sensor against different biological samples was examined in the NIR region. It was observed that the sensor was selective against dopamine. In the study conducted in the 10-100 µM linear range, it was observed that an increase in fluorescence intensity occurred due to increasing dopamine (DA) concentration. The limit of detection (LOD) of the sensor was calculated as 4.2 × 10- 5 M, and the significant limit of quantification (LOQ) was calculated as 13.24 × 10- 5 M. With these features, the (GTA)20-SWCNT biosensor has the potential to be used as an innovative tool in DA detection.
