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Updated: Apr 16, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Vision and migraine.

Maurice B Vincent1

  • 1Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

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This summary is machine-generated.

Cortical spreading depression (CSD) underlies migraine aura and visual disturbances. Migraine medications can reduce CSD, and vision

Keywords:
blindnesscortical spreading depressionmigraine auravision

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neurology

Background:

  • Migraine is a common neurological disorder significantly impacting visual function.
  • Visual aura symptoms in migraine range from simple light flashes to complex hallucinations.
  • The timing, presentation, and varied phenotypes of migraine aura remain poorly understood.

Purpose of the Study:

  • To elucidate the nature of visual disturbances in migraine.
  • To investigate the role of cortical spreading depression (CSD) in migraine.
  • To explore the influence of vision on migraine aura characteristics.

Main Methods:

  • Review of evidence on visual perceptions in migraine.
  • Analysis of the relationship between vision and migraine.
  • Examination of the role of cortical spreading depression (CSD).
  • Assessment of how vision impacts migraine.

Main Results:

  • CSD propagates at a rate consistent with visual field symptom progression.
  • Neuroimaging confirms CSD-related changes in migraineurs, with or without aura.
  • Computational models of CSD in the visual cortex align with observed aura phenomena.
  • Migraine prophylactic drugs modulate CSD by increasing threshold and reducing velocity.
  • Blind individuals with migraine may experience altered aura, including sensory variations.

Conclusions:

  • CSD is the fundamental mechanism in both migraine with and without aura.
  • In migraine without aura, CSD may not reach cortical areas that trigger symptoms.
  • Normal vision is crucial; its absence can alter aura experiences due to cortical plasticity and CSD susceptibility.