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Updated: Apr 16, 2026
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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Pediatric systemic lupus erythematosus in a single nephrology unit
Doaa Mohammed Youssef1, Doaa Mostafa Tawfek, Abdelsalam Mohammed Mohammed
1Department of Pediatric Nephrology, Zagazig University, Zagazig, Egypt.
Summary
Systemic lupus erythematosus (SLE) in children presents variably, with fever and lupus nephritis being common. Children without lupus nephritis experienced better outcomes and higher remission rates compared to those with it.
Area of Science:
- Pediatric Rheumatology
- Immunology
- Systemic Autoimmune Diseases
Background:
- Systemic lupus erythematosus (SLE) exhibits diverse clinical features and unpredictable progression.
- Childhood-onset SLE is often considered more severe than adult-onset SLE.
Purpose of the Study:
- To investigate the clinical presentation and outcomes of pediatric SLE patients.
- To compare outcomes between pediatric SLE patients with and without lupus nephritis.
Main Methods:
- Retrospective analysis of 26 children (ages 5-18) diagnosed with SLE between 2005 and 2011.
- Evaluation included clinical assessment, laboratory tests (CBC, ESR, C3, urinalysis, 24-h urinary protein, ANA, anti-ds DNA), and renal biopsy where indicated.
Main Results:
- Fever (57.7%) was the most frequent extra-renal manifestation, and lupus nephritis (50%) was the most common organ involvement.
- Hemolytic anemia (80.8%) was the predominant hematological abnormality; all patients had positive immunological markers.
- Remission rates were over 5.3 times higher in patients without lupus nephritis, who also showed better overall outcomes.
Conclusions:
- Pediatric SLE presentation includes fever and lupus nephritis, with significant hematological abnormalities.
- The presence of lupus nephritis is associated with poorer outcomes and lower remission rates in children with SLE.
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