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Differential distribution of probenecid as detected by on-tissue mass spectrometry
Yulin Qi1, Nadine Hainz, Thomas Tschernig
1Institute for Bioanalytical Chemistry, Saarland University, Kirrberger Straße, Trigonum Vesalii, 66424, Homburg, Saar, Germany.
Cell and Tissue Research
|March 12, 2015
Abstract:
We demonstrate, by means of on-tissue mass spectrometry of tissue sections, that the drug probenecid can penetrate the blood-brain barrier. This method holds general promise for the detection and distribution of small molecule drugs within organ and tissue compartments.
