Lipid metabolism disorders and bone dysfunction--interrelated and mutually regulated (review)

Area of Science:

• Endocrinology and Metabolism
• Bone Biology and Disease
• Cardiovascular Science

Background:

• Atherosclerosis (AS) and osteoporosis (OP) frequently co-exist, suggesting a link between lipid and bone metabolism.
• Multipotent mesenchymal stem cells (MSCs) in bone marrow are progenitors for both adipocytes and osteoblasts.
• Evidence indicates a reciprocal regulatory relationship between lipid and bone metabolism.

Purpose of the Study:

• To review the association between lipid metabolism disturbance and osteoporosis.
• To explore the biological, pathophysiological, and clinical evidence supporting this link.
• To examine adipocyte and osteoblast differentiation and pharmacological interventions.

Main Methods:

• Review of laboratory-based and clinical trial data.
• Analysis of experimental animal studies.
• Examination of differentiation pathways and pharmacological effects.

Main Results:

• Increased adipocyte differentiation correlates with decreased bone mineral density (BMD) and bone mass.
• Statins, used for hyperlipidemia, show therapeutic benefits for OP.
• Biological and pathophysiological mechanisms link lipid metabolism to bone health.

Conclusions:

• Lipid metabolism dysregulation is significantly associated with osteoporosis.
• Understanding the interplay between fat and bone metabolism is crucial for treating co-existing AS and OP.
• Targeting shared pathways may offer novel therapeutic strategies.