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Updated: Apr 16, 2026
A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
Published on: September 10, 2014
A reusable microRNA sensor based on the electrocatalytic property of heteroduplex-templated copper nanoclusters
Zhaoyin Wang1, Ling Si, Jianchun Bao
1Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials and Jiangsu key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, P. R. China. daizhihuii@ninu.edu.cn.
Abstract:
DNA-RNA heteroduplexes have been used as templates for copper nanocluster (CuNC) formation for the first time. Taking advantage of the electrocatalysis of CuNCs, quantitation of miRNA can thus be accomplished. More importantly, by simply operating several rounds of CuNC formation, repeated detection of miRNA has further been realized, which is rare in miRNA biosensors.
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