Related Experiment Video
Updated: Apr 16, 2026
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Adequate antimicrobial drug use in a third level pediatric hospital]
Fidencia Duarte-Raya1, Manuel Rodríguez-Lechuga, Manuel Alberto De Anda-Gómez
1División de Epidemiología, Hospital de Gineco-Pediatría 48 León, León, Guanajuato, México. catanitaduarte@gmail.com.
Insights
Proper antimicrobial use in pediatric patients is crucial to combat bacterial resistance. This study found only 51.2% of antimicrobial treatments were prescribed appropriately in hospitalized children, highlighting a need for improved antimicrobial stewardship.
Area of Science:
- Pediatric infectious diseases
- Antimicrobial stewardship
- Bacterial resistance
Background:
- Inadequate antimicrobial use fuels bacterial resistance, reduces treatment efficacy, and increases mortality.
- Evaluating proper antimicrobial prescribing in pediatric hospital settings is essential.
Purpose of the Study:
- To assess the appropriateness of antimicrobial drug use in hospitalized pediatric patients.
- To identify patterns and potential areas for improvement in pediatric antimicrobial prescribing.
Main Methods:
- An observational, cross-sectional epidemiological study was conducted.
- 283 antimicrobial prescriptions from 217 pediatric patients were analyzed.
- Statistical analysis, including chi-square tests, was used to compare treatment appropriateness.
Main Results:
- Overall, 51.2% of antimicrobial treatments were deemed adequate.
- Adequate treatment was associated with the neonates service (p=0.004), while inadequate treatment was noted in preterm infants (p=0.028).
- Penicillins (43.7%) and aminoglycosides (37.1%) were the most frequently prescribed antimicrobials.
Conclusions:
- Approximately half of all prescribed antimicrobial treatments in this pediatric cohort were appropriate.
- Findings underscore the need for enhanced antimicrobial stewardship programs in pediatric care settings.
Background:
The inadequate use of antimicrobials contributes to the development of bacterial resistance, reduces the effectiveness of established treatments and increases costs and mortality due to infectious diseases. The aim of this article was to evaluate if the use of antimicrobials was carried out properly in hospitalized pediatric patients.
Methods:
An epidemiological observational, cross-sectional study was carried out in UMAE-48 in León, Guanajuato. Sample was non-probabilistic by convenience with 60 % of expected adequate treatments, 4 standard deviation. Analysis of statistical distribution frequency technique was used by type of final grade of each treatment that was administered: adequate, justified, therapeutic, restricted and prophylactic. The test chi-square test for comparing of percentages.
Results:
Antimicrobial therapy were evaluated 283 prescriptions in 217 patients, 53 % were men and 47 % women. The general treatment was adequate in 51.2 %, justified 66 %, therapeutic 53.4 %, 40.8 % restricted and 48% prophylactic. Comparison of percentages with statistical test of chi-square test, we found association with adequate treatment in neonates service (chi-square test 8.287; p 0.004) and inadequate treatment in preterm infants service (chi-square test 4.853; p 0.028) p < 0, 05. The most commonly used antimicrobials, 43.7 % penicillins and 37.1 % aminoglycoside.
Conclusion:
Only half of the treatments was antimicrobials are prescribed properly.
More Related Videos
12:03Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
Published on: April 18, 2019
09:17A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
Published on: January 2, 2017
Related Concept Videos
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
01:29Drug Dosing: Infants and Children
01:28Antimicrobial Effectiveness
01:22Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution