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PTEN: Multiple Functions in Human Malignant Tumors

Michele Milella1, Italia Falcone1, Fabiana Conciatori1

  • 1Division of Medical Oncology A, Regina Elena National Cancer Institute , Rome , Italy.

Frontiers in Oncology
|March 13, 2015
PubMed
Summary

The tumor suppressor PTEN negatively regulates PI3K signaling and impacts cell survival, proliferation, and genomic stability. Dysregulation of PTEN, through various molecular mechanisms, contributes to human cancers.

Keywords:
PHTSPI3KPTENcancersubcellular localization

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