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Updated: Apr 16, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
Published on: June 3, 2018
Reprogramming for cardiac regeneration
Christophe Michel Raynaud1, Faizzan Syed Ahmad, Mona Allouba2
1Qatar Cardiovascular Research Center, Qatar Foundation-Education City, Doha, Qatar.
Abstract:
Treatment of cardiovascular diseases remains challenging considering the limited regeneration capacity of the heart muscle. Developments of reprogramming strategies to create in vitro and in vivo cardiomyocytes have been the focus point of a considerable amount of research in the past decades. The choice of cells to employ, the state-of-the-art methods for different reprogramming strategies, and their promises and future challenges before clinical entry, are all discussed here.

