[Research advance on angiogenesis in ischemic heart induced by aerobic exercise and stem cell mobilization]

Aerobic exercise has specific angiogenesis effect, also in the ischemic heart. But its mechanism has not been fully clarified. Coronary microvascular angiogenesis is the precondition of heart repair after myocardial infarction (MI). Recent studies have shown that angiogenesis is caused by endogenous stem cell/progenitor mobilization and participation, and its paracrine effects on endothelial cells (EC) function and microvascular distribution. Exercise could mobilize and activate the expression and secretion of endogenous stem cell and angiogenic factors, and affect the cardiac angiogenesis in epigenetics. Investigating the effect of different exercise methods and intension on ischemic cardiac angiogenesis and its molecular mechanism are of great significance on prevention and postoperative rehabilitation of MI. This review summarized the main mechanism, existing problems and related research progress on exercise improving ischemic cardiac angiogenesis through cardiac angiogenesis and its regulation mechanisms, endogenous stem cell mobilization and participates in angiogenesis of ischemic heart, and exercise improving ischemic cardiac angiogenesis through stem cell mobilization.