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Different effects of ANP and nitroprusside on cyclic GMP extrusion of isolated aorta
J P Stasch1, S Kazda, D Neuser
1Bayer AG, Institute of Pharmacology, Wuppertal, F.R.G.
Abstract:
Atrial natriuretic peptide (ANP) and sodium nitroprusside have potent vasodilator effects on the noradrenaline-precontracted isolated rabbit aorta. A distinct elevation of cyclic GMP in the aortic tissue was observed after both vasodilators. In contrast to sodium nitroprusside, ANP-(5-28) induced a dose-dependent cyclic GMP extrusion from the tissue into the medium. Thus, release of cyclic GMP appears to be specific for activation of particulate guanylate cyclase and provides a mechanism in addition to synthesis and degradation by which the cells can regulate their internal concentrations of cyclic GMP.
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