Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Stroke Volume

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial.

Human brain mapping·2026

Same author

Stroke and its consequences: protocol and pilot data of the observational Berlin Long-term Observation of Vascular Events (BeLOVE) stroke stratum.

BMJ neurology open·2026

Same author

Social media activities to enhance the visibility of long-term invasive ventilation: A content and visibility analysis from the PRiVENT study.

PloS one·2026

Same author

Who Falls After a Stroke? Evidence From a Prospective Stroke Cohort.

European journal of neurology·2026

Same author

Oedema reduction mediates thrombectomy benefit in large core stroke: secondary analysis of the TENSION trial.

European stroke journal·2026

Same author

Microcirculatory Collaterals Modulate Ischemic Core Heterogeneity on Diffusion-Weighted Imaging.

AJNR. American journal of neuroradiology·2026

Search research articles

Related Experiment Video

Updated: Apr 16, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Infarct volume-based subgroup selection in acute ischemic stroke trials.

Anna Kufner¹, Anke Wouters², Luc Bracoud²

¹From the Department of Neurology, Center for Stroke Research Berlin, Charité University Hospital Berlin, Germany (A.K., J.B.F.); Experimental Neurology, Department of Neurosciences, KU Leuven-University of Leuven, Leuven, Belgium (A.W., V.T.); Department of Neurology, BioClinica Bio-Imaging Technologies, Lyon France (L.B.); Department of Neurology, Sygnis Bioscience, Im Neuenheimer Feld 515, Heidelberg, Germany (R.L., A.S.); Department of Neurology, Evangelisches Krankenhaus Bielefeld, Germany (W.-R.S.); Department of Neuroradiology, Hospices Civils de Lyon, France (M.H.); VIB, Vesalius Research Center, Laboratory of Neurobiology, B-3000 Leuven, Belgium (V.T.); and Department of Neurology, University Hospitals Leuven, Leuven, Belgium (V.T.). anna.kufner@charite.de.

|March 14, 2015

Summary

Diffusion-weighted imaging lesion diameter measurements can help select acute stroke patients for clinical trials. A 3 cm diameter on diffusion-weighted imaging shows high sensitivity for identifying infarcts of at least 15 mL.

Keywords:

clinical trial infarction stroke

More Related Videos

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Published on: December 28, 2014

Related Experiment Videos

Last Updated: Apr 16, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping

Published on: September 25, 2019

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Stereological and Flow Cytometry Characterization of Leukocyte Subpopulations in Models of Transient or Permanent Cerebral Ischemia

Published on: December 28, 2014

Area of Science:

Neurology
Radiology
Medical Imaging

Background:

Acute stroke patient selection for clinical trials requires precise infarct volume assessment.
Diffusion-weighted imaging (DWI) is a key tool in acute stroke evaluation.
Multicenter trials necessitate reliable and efficient patient recruitment methods.

Purpose of the Study:

To determine if DWI lesion diameter measurements can predict a minimum infarct volume of 15 mL.
To evaluate the efficacy of different DWI hyperintensity diameter cut-offs (3, 3.5, and 4 cm) for patient selection.
To assess the potential of DWI diameter as a surrogate for infarct volume in multicenter stroke trials.

Main Methods:

Consecutive acute stroke patients from the AXIS2 trial were screened.
A standardized magnetic resonance imaging protocol was applied across 65 sites.
Diffusion-weighted lesion diameters were measured and compared with volumetric infarct assessments.

Main Results:

86.2% of patients had an infarct diameter of at least 3 cm.
A 3 cm DWI lesion diameter achieved 96.8% sensitivity and 33.3% specificity for predicting an infarct volume ≥15 mL.
Increasing the diameter cut-off to 3.5 cm improved specificity to 50.6% (96.8% sensitivity), and 4 cm improved specificity to 61.7% (91.7% sensitivity).

Conclusions:

Lesion diameter measurements on DWI can facilitate multicenter patient recruitment.
DWI diameter serves as a feasible method for identifying patients with prespecified minimal infarct volumes.
This approach aids in standardizing patient selection for acute stroke clinical trials.