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Updated: Apr 16, 2026
Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
Published on: July 13, 2019
[Epidemiological and basic research activity targeting polyomaviruses]
Hirofumi Sawa1, Shintaro Kobayashi, Tadaki Suzuki
1Division of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control.
Abstract:
Recently, the family Polyomaviridae was classified as 3 genera, such as Orthopolyomavirus, Wukipolyomavirus which contain mammalian polyomaviruses and Avipolyomavirus which only contain avian polyomaviruses. We have recently isolated novel polyomaviruses, including Mastomys Polyoamvirus (MasPyV) and Vervet monkey Polyoamvirus-1 (VmPyV-1) by epidemiological activities and examined functions of their encoding proteins. In addition, we have been investigating the mechanisms of replication of human polyomavirus, JC polyomavirus (JCPyV). We recently obtained the results of function of JCVPyV-encoding proteins, including early protein (Large T antigen) and late proteins (VP1 and Agno). In this review, we summarized the data of our basic research activities.
Insights
Researchers explored novel polyomaviruses, Mastomys polyomavirus (MasPyV) and Vervet monkey polyomavirus-1 (VmPyV-1), and investigated JC polyomavirus (JCPyV) replication mechanisms and protein functions.
Area of Science:
- Virology
- Molecular Biology
- Genomics
Context:
- The family Polyomaviridae is now classified into three genera: Orthopolyomavirus, Wukipolyomavirus (mammalian), and Avipolyomavirus (avian).
- Recent epidemiological studies have led to the isolation of novel polyomaviruses.
Purpose:
- To review recent basic research on polyomaviruses.
- To examine the functions of proteins encoded by newly isolated polyomaviruses, MasPyV and VmPyV-1.
- To investigate the replication mechanisms and protein functions of human JC polyomavirus (JCPyV).
Summary:
- Novel mammalian polyomaviruses, Mastomys polyomavirus (MasPyV) and Vervet monkey polyomavirus-1 (VmPyV-1), were isolated and their encoded proteins analyzed.
- Research on JC polyomavirus (JCPyV) focused on the functional characterization of its early protein (Large T antigen) and late proteins (VP1, Agno).
- This review consolidates findings from ongoing basic research into polyomavirus replication and protein functions.
Impact:
- Contributes to a deeper understanding of polyomavirus diversity and evolution.
- Provides insights into the molecular mechanisms underlying polyomavirus replication and pathogenesis.
- Establishes a foundation for future research into polyomavirus-associated diseases and therapeutic strategies.
