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Updated: Apr 16, 2026

HKUST-1 as a Heterogeneous Catalyst for the Synthesis of Vanillin
Published on: July 23, 2016
Solubility and thermodynamic function of vanillin in ten different environmentally benign solvents
Faiyaz Shakeel1, Nazrul Haq1, Nasir A Siddiqui2
1Research Center, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Abstract:
The solubility of vanillin in ten different environmentally benign solvents namely water, ethanol, ethylene glycol (EG), ethyl acetate (EA), isopropanol (IPA), propylene glycol (PG), polyethylene glycol-400 (PEG-400), Transcutol, butanol-1 and butanol-2 was measured and correlated at T=(298-318)K. The resulting experimental data were correlated with the modified Apelblat and Van't Hoff models. Both the models showed good correlation of experimental solubility data with calculated ones with root mean square deviations in the range of (0.08-1.55)%. The mole fraction solubility of vanillin was observed highest in PEG-400 (4.29 × 10(-1) at 298 K) followed by Transcutol, EA, butanol-2, ethanol, EG, PG, IPA, butanol-1 and water from T=(298-318)K. The results of thermodynamic function in terms of dissolution enthalpy, Gibbs energy and dissolution entropy showed endothermic, spontaneous and entropy-driven dissolution of vanillin in all environmentally benign solvents.
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