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Updated: Apr 16, 2026

Time-Lapse Video Microscopy for Assessment of EYFP-Parkin Aggregation as a Marker for Cellular Mitophagy
Published on: May 4, 2016
The role of autophagy in Parkinson's disease
Lei Zhang1, Yaru Dong2, Xiaoheng Xu1
1Department of Pediatrics, the Second Hospital of Jilin University, Changchun 130041, Jilin Province, China.
Abstract:
Although Parkinson's disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson's disease. This review summarizes the most recent findings and discusses the unique role of the autophagy-lysosome pathway in Parkinson's disease to highlight the possibility of Parkinson's disease treatment strategies that incorporate autophagy-lysosome pathway modulation.
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