Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:19

Cell Migration

7.5K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
7.5K
Cell Migration01:09

Cell Migration

19.2K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
19.2K
Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

3.5K
Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
3.5K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

3.8K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
3.8K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

5.8K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
5.8K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

6.3K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
6.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The MYB-related transcription factor MYPOP acts as a selective regulator of cancer cell growth.

Communications biology·2026
Same author

Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia.

Nature communications·2025
Same author

CETSA-MS unveils novel targets engaged by rigosertib to promote anti-tumor activity and inflammatory responses.

iScience·2025
Same author

HSP110 Regulates the Assembly of the SWI/SNF Complex.

Cells·2025
Same author

Unveiling IRF4-steered regulation of context-dependent effector programs in CD4<sup>+</sup> T cells under Th17- and Treg-skewing conditions.

Cell reports·2025
Same author

Integrate and conquer: pan-cancer proteogenomics uncovers cancer vulnerabilities and therapeutic opportunities.

Signal transduction and targeted therapy·2024
Same journal

Editorial for special issue "When should mathematical models be used in biology".

Seminars in cell & developmental biology·2026
Same journal

Conserved machinery, divergent functions: evolutionary plasticity of the STK36/ULK4 kinase complex in ciliogenesis and signaling.

Seminars in cell & developmental biology·2026
Same journal

Chemical biology tools for studying tissue development.

Seminars in cell & developmental biology·2026
Same journal

Tetrahymena as a model organism for cilia research.

Seminars in cell & developmental biology·2026
Same journal

Emerging Concepts in Cardiovascular Development and Regeneration.

Seminars in cell & developmental biology·2026
Same journal

Endothelial origin of hematopoietic stem cells: Insights from new technologies and unresolved questions.

Seminars in cell & developmental biology·2026
See all related articles

Related Experiment Video

Updated: Apr 16, 2026

In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

142.2K

IAPs and cell migration.

Laurence Dubrez1, Krishnaraj Rajalingam2

  • 1Institut National de la Santé et de la Recherche Médicale (Inserm) UMR866, Dijon F-21079, France; Université de Bourgogne, Dijon F-21079, France.

Seminars in Cell & Developmental Biology
|March 15, 2015
PubMed
Summary
This summary is machine-generated.

Inhibitors of apoptosis (IAPs) regulate cell signaling and are increasingly linked to cell migration. This study explores the specific mechanisms through which IAPs control cell movement.

Keywords:
IAPsInvasionMigrationRhoGTPasesSignalingUbiquitination

More Related Videos

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager
09:17

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager

Published on: February 2, 2019

8.3K
Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

9.1K

Related Experiment Videos

Last Updated: Apr 16, 2026

In vitro Cell Migration and Invasion Assays
09:55

In vitro Cell Migration and Invasion Assays

Published on: June 1, 2014

142.2K
A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager
09:17

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager

Published on: February 2, 2019

8.3K
Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

9.1K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Inhibitors of apoptosis (IAPs) are crucial regulators of fundamental cellular processes.
  • Emerging research suggests IAPs play a role in modulating cell invasion and migration.

Purpose of the Study:

  • To elucidate the mechanisms by which IAPs influence cell migration.
  • To provide a comprehensive overview of IAP-mediated control over cell motility.

Main Methods:

  • Literature review and synthesis of existing in vivo and in vitro studies.
  • Analysis of signaling pathways and molecular interactions involving IAPs in cell migration.

Main Results:

  • IAPs can modulate cell migration through various signaling pathways.
  • Specific IAP proteins and their targets are involved in regulating cell motility.

Conclusions:

  • IAPs are significant regulators of cell migration.
  • Understanding IAP function in cell migration may offer therapeutic targets for diseases involving aberrant cell movement.