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Updated: Apr 16, 2026

Optimization of Transesophageal Atrial Pacing to Assess Atrial Fibrillation Susceptibility in Mice
Published on: June 29, 2022
Diabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapies
Christos A Goudis1, Panagiotis Korantzopoulos2, Ioannis V Ntalas2
1Department of Cardiology, General Hospital of Grevena, Greece.
Abstract:
Diabetes mellitus (DM) represents one of the most important risk factors for atrial fibrillation (AF) while AF is a strong and independent marker of overall mortality and cardiovascular morbidity in diabetic patients. Autonomic, electrical, electromechanical, and structural remodeling, including oxidative stress, connexin remodeling and glycemic fluctuations seem to be implicated in AF pathophysiology in the setting of DM. The present review highlights the association between DM and AF, provides a comprehensive overview of the responsible pathophysiological mechanisms and briefly discusses potential upstream therapies for DM-related atrial remodeling.
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