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Updated: Apr 16, 2026

Detecting Pre-Stimulus Source-Level Effects on Object Perception with Magnetoencephalography
Published on: July 26, 2019
For things needing your attention: the role of neocortical gamma in sensory perception
Dominique L Pritchett1, Joshua H Siegle2, Christopher A Deister3
1Champalimaud Neuroscience Program, Lisbon, Portugal.
Abstract:
Two general classes of hypotheses for the role for gamma oscillations in sensation are those that predict gamma facilitates signal amplification through local synchronization of a distinct ensemble, and those that predict gamma modulates fine temporal relationships between neurons to represent information. Correlative evidence has been offered for and against these hypotheses. A recent study in which gamma was optogenetically entrained by driving fast-spiking interneurons showed enhanced sensory detection of harder-to-perceive stimuli, those that benefit most from attention, in agreement with the amplification hypotheses. These findings are supported by similar studies employing less specific optogenetic patterns or single neuron stimulation, but contrast with findings based on direct optogenetic stimulation of pyramidal neurons. Key next steps for this topic are described.
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