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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
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Long non-coding RNAs control hematopoietic stem cell function.

Min Luo1, Mira Jeong1, Deqiang Sun2

  • 1Stem Cells and Regenerative Medicine Center, Department of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Cell Stem Cell
|March 17, 2015
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) regulate hematopoietic stem cell (HSC) identity and function. Researchers identified novel lncRNAs in HSCs, finding they impact self-renewal and lineage commitment, revealing a new layer of gene regulation.

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Area of Science:

  • * Hematology
  • * Molecular Biology
  • * Genomics

Background:

  • * Hematopoietic stem cells (HSCs) maintain blood cell production through precise gene expression.
  • * Long non-coding RNAs (lncRNAs) are implicated in gene regulation and cell fate, but their role in HSCs is largely unknown.

Purpose of the Study:

  • * To identify and characterize novel lncRNAs in HSCs.
  • * To investigate the functional significance of these lncRNAs in HSC self-renewal and differentiation.

Main Methods:

  • * Deep sequencing of purified HSC transcriptomes.
  • * Comparative expression analysis across HSCs and differentiated lineages.
  • * LncRNA knockdown experiments and genomic binding site mapping.

Main Results:

  • * Discovery of 323 unannotated lncRNAs in HSCs.
  • * Identification of 159 lncRNAs enriched in HSCs, potentially HSC-specific (LncHSCs).
  • * Demonstrated functional impact of LncHSCs on HSC self-renewal and lineage commitment, with one candidate binding to hematopoietic transcription factors like E2A.

Conclusions:

  • * LncRNAs represent a significant regulatory layer in HSC biology.
  • * Identified LncHSCs offer new targets for understanding and manipulating HSC function.