Related Experiment Video
Updated: Jul 25, 2026

09:29
An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
Published on: May 13, 2020
12.9K
Modeling an irritant gas plume for epidemiologic study.
Dev D Jani1, David Reed2, Charles E Feigley3
1a Department of Global Environmental Health Sciences , Tulane University School of Public Health and Tropical Medicine , New Orleans , LA , USA.
International Journal of Environmental Health Research
|March 17, 2015
Summary
This study modeled a chlorine release using plume dispersion models. The Hazard Prediction and Assessment Capability (HPAC) model showed promise for future epidemiologic studies on chemical hazard exposure.
Area of Science:
- Environmental Science
- Toxicology
- Epidemiology
Background:
- Plume dispersion modeling is crucial for assessing human exposure to chemical hazards in epidemiologic studies.
- Accurate modeling is essential for understanding the impact of hazardous material releases.
Purpose of the Study:
- To model the dispersion of a chlorine release from a 2005 Graniteville, South Carolina railcar incident.
- To compare the performance of two plume dispersion modeling systems: Areal Locations of Hazardous Atmospheres and Hazard Prediction and Assessment Capability (HPAC).
- To evaluate the suitability of these models for future epidemiologic studies.
Main Methods:
- Modeled a 54,915 kg chlorine railcar release using engineering analysis for release rate estimation.
- Employed both Areal Locations of Hazardous Atmospheres and Hazard Prediction and Assessment Capability (HPAC) plume modeling systems.
- Validated regional meteorological data by comparing concentration estimates from two weather datasets.
Main Results:
- The HPAC model predicted a chlorine plume with outdoor concentrations reaching 20 ppm up to 7 km downwind.
- The model also indicated significant plume spread upwind and downgrade (0.25 km).
- Comparative analysis identified HPAC as a strong candidate for epidemiologic study support.
Conclusions:
- The Hazard Prediction and Assessment Capability (HPAC) model demonstrated potential for supporting epidemiologic studies on chemical exposures.
- Further validation of the HPAC model is required for reliable individual exposure estimations and definitive plume modeling.
- The study highlights the importance of advanced modeling in understanding and mitigating the effects of hazardous chemical releases.

