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Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
Published on: September 30, 2019
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The Fibroblast Growth Factor signaling pathway
David M Ornitz1, Nobuyuki Itoh
1Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
Wiley Interdisciplinary Reviews. Developmental Biology
|March 17, 2015
Summary
Mammalian Fibroblast Growth Factors (FGFs) are crucial signaling proteins regulating development and tissue repair. Aberrant FGF signaling is linked to developmental defects, metabolic disorders, and cancer.
Area of Science:
- Cell Biology
- Developmental Biology
- Biochemistry
Background:
- The Fibroblast Growth Factor (FGF) family comprises 18 secreted proteins and 4 FGF receptors (FGFRs).
- FGF signaling is modulated by cofactors and extracellular binding proteins.
- Intracellular non-signaling FGFs also regulate voltage-gated sodium channels.
Purpose of the Study:
- To provide a comprehensive overview of the FGF signaling pathway.
- To highlight the diverse roles of FGFs in embryonic development and adult tissue homeostasis.
- To discuss the implications of aberrant FGF signaling in disease.
Main Methods:
- Review of existing literature on FGF signaling.
- Analysis of FGF family members, receptors, and associated pathways.
- Synthesis of information on FGF functions and dysregulation.
Main Results:
- FGFs are essential for embryonic development, organogenesis, and progenitor cell maintenance.
- Activated FGFRs trigger intracellular pathways like RAS-MAPK, PI3K-AKT, PLCγ, and STAT.
- FGFs play roles in adult tissue repair, regeneration, and metabolic functions.
Conclusions:
- FGF signaling is fundamental to numerous biological processes from development to adult tissue function.
- Dysregulation of FGF pathways contributes to various pathologies, including developmental disorders, metabolic diseases, and cancer.
- Understanding FGF signaling is critical for addressing a wide range of human diseases.
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