Related Experiment Video
Updated: Apr 16, 2026
07:59
Molecular Entanglement and Electrospinnability of Biopolymers
Published on: September 3, 2014
15.2K
Triboelectrification and dissolution property enhancements of solid dispersions
Kofi Asare-Addo1, Enes Šupuk1, Hiba Al-Hamidi2
1Department of Pharmacy, University of Huddersfield, Huddersfield HD1 3DH, UK.
International Journal of Pharmaceutics
|March 17, 2015
Summary
Glucosamine hydrochloride (GLU) solid dispersions with indomethacin improved drug dissolution. Solvent choice significantly impacted particle charge, influencing both powder handling and dissolution properties.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Physical Chemistry
Background:
- Solid dispersion techniques enhance drug solubility and dissolution but can alter particle electrostatic properties.
- Particle triboelectrification is crucial in powder processing, affecting quality through deposition and loss.
- Understanding electrostatic properties is key for optimizing powder handling and drug delivery.
Purpose of the Study:
- To investigate the triboelectrical charging of indomethacin-glucosamine hydrochloride (GLU) solid dispersions.
- To evaluate the impact of different solvents on the electrostatic properties and dissolution rates of these dispersions.
- To correlate solvent selection with particle charge and powder handling characteristics.
Main Methods:
- Preparation of indomethacin-GLU solid dispersions using various solvents (acetone, ethanol, and their aqueous mixtures).
- Solid-state characterization using Differential Scanning Calorimetry (DSC), Fourier-Transform Infrared Spectroscopy (FTIR), and X-ray Powder Diffraction (XRPD).
- Measurement of particle charge using a custom-built device with a Faraday cup and electrometer.
Main Results:
- All solid dispersions enhanced the dissolution rate of indomethacin.
- Preparation methods induced polymorphic changes in indomethacin.
- Indomethacin exhibited high negative charging (-411 nC/g), while GLU showed minimal charging (-1 nC/g).
- Dispersions displayed low charges (-1 to 14 nC/g).
- Acetone-based solvents yielded electronegative charges, whereas ethanol-based solvents resulted in electropositive charges.
Conclusions:
- Solvent selection critically influences the powder charge of indomethacin-GLU solid dispersions.
- Optimizing solvent choice can improve both powder handling and dissolution properties.
- This study highlights the interplay between solid dispersion formulation, solvent effects, and triboelectrification in pharmaceutical processing.
Related Concept Videos
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
879
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
879
02:28Intermolecular Forces in Solutions
41.2K
The formation of a solution is an example of a spontaneous process, a process that occurs under specified conditions without energy from some external source.
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
When the strengths of the intermolecular forces of attraction between solute and solvent species in a solution are no different than those present in the separated components, the solution is formed with no accompanying energy change. Such a solution is called an ideal solution. A mixture of ideal gases (or gases such as helium and argon,...
41.2K
01:15Theories of Dissolution: Diffusion Layer Model
2.3K
Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
2.3K
01:27Factors Influencing Drug Absorption: Drug Dissolution
1.8K
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
1.8K
01:29The Colloidal State
164
The formation of a colloidal system is exemplified by an aqueous solution containing Cl− ions is introduced to another containing Ag+ ions, resulting in the precipitation of solid AgCl as extremely tiny crystals. Instead of settling out as a filterable precipitate, these crystals remain suspended in the liquid, showcasing a colloidal system.A colloidal system involves colloidal particles within the approximate range of 1 to 1000 nm in at least one dimension, dispersed in a medium called...
164
01:20Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
696
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
696