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Updated: Apr 16, 2026

Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
A Ag-molecularly imprinted polymer composite for efficient surface-enhanced Raman scattering activities under a
1Department of Chemistry, Harbin Institute of Technology, Harbin 150090, China. lixin@hit.edu.cn.
Abstract:
In this work, we have fabricated flower-shaped Ag particles coated with a molecularly imprinted polymer (Ag@MIP) based on the molecular imprinting technique and SERS technology. Although Raman signals decrease with the reducing laser power, Ag@MIP could sensitively detect the target molecules even at a laser power as low as 0.14 μW. As a new SERS substrate, Ag@MIP shows high enhancement under low irradiation effectively, which limits the possible laser induced effects in the measurement process, improving the signal-to-noise ratio and repeatability. This platform has potential for the development of next-generation SERS spectroscopy.
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