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Related Experiment Videos

Intraperitoneal Vancoled does not cause chemical peritonitis.

C A Johnson1, S W Zimmerman, S Engeseth

  • 1Department of Medicine, University of Wisconsin Hospital, Madison.

Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis
|January 1, 1989
PubMed
Summary

Intraperitoneal vancomycin loading doses did not cause chemical peritonitis in patients with catheter exit-site infections. This study found the treatment well-tolerated, with no adverse effects observed in the participants.

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pharmacology

Background:

  • Previous studies suggested intraperitoneal vancomycin loading doses may induce chemical peritonitis.
  • Catheter-related infections, particularly exit-site infections, are a common complication in patients undergoing peritoneal dialysis.

Purpose of the Study:

  • To evaluate the safety and potential for chemical peritonitis of a 30 mg/kg intraperitoneal vancomycin loading dose.
  • To assess the impact of this vancomycin loading dose on peritoneal fluid parameters and patient tolerance in the context of exit-site infections.

Main Methods:

  • Open-label study involving five patients with culture-positive, erythematous, draining exit-site infections.
  • Administration of a 30 mg/kg intraperitoneal vancomycin loading dose after draining existing dialysate.

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  • Collection of peritoneal dialysate samples at baseline, 2 hours, and 4 hours for cell count and culture.
  • Measurement of serum vancomycin concentrations at 4 hours post-administration.

    • Main Results:

    • Baseline dialysate white blood cell counts were below 9 cells/µL.
    • Post-dosing dialysate cell counts remained low (2-hour: <4 cells/µL; 4-hour: <11 cells/µL).
    • All dialysate and fluid samples were sterile, with unremarkable white blood cell differential counts and no reported adverse effects.

    Conclusions:

    • Intraperitoneal vancomycin loading doses did not induce chemical peritonitis in patients with exit-site infections.
    • The administration of vancomycin via intraperitoneal loading dose was well-tolerated in this patient cohort.
    • Findings suggest current protocols for vancomycin loading doses in this context are safe.