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Related Experiment Videos

Acid base correction in bicarbonate CAPD patients.

M Feriani1, S Biasioli, S Barbacini

  • 1Department of Nephrology, St. Bortolo Hospital, Vicenza, Italy.

Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis
|January 1, 1989
PubMed
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This study shows that bicarbonate solutions for continuous ambulatory peritoneal dialysis (CAPD) achieve equilibrium when dialysate bicarbonate is 5 mmol/l higher than blood levels. This ensures stable acid-base balance in patients.

Area of Science:

  • Nephrology
  • Biochemistry

Background:

  • Bicarbonate is a proposed buffer in continuous ambulatory peritoneal dialysis (CAPD) solutions, replacing lactate and acetate.
  • Understanding peritoneal bicarbonate kinetics is crucial for optimizing CAPD therapy.

Purpose of the Study:

  • To evaluate peritoneal bicarbonate kinetics in patients undergoing CAPD using bicarbonate-containing solutions.
  • To determine the relationship between dialysate and blood bicarbonate concentrations during CAPD.

Main Methods:

  • Seventy kinetic studies were conducted in 7 patients using two CAPD solutions with different bicarbonate concentrations (35 mmol/l and 27 mmol/l).
  • Dialysate bicarbonate changes over time were correlated with blood bicarbonate levels.

Main Results:

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  • A feedback mechanism between bicarbonate absorption and blood concentration was observed.
  • No significant difference in dialysate bicarbonate concentration was found between the two solutions at equivalent blood bicarbonate levels.
  • Equilibrium, where bicarbonate absorption matches metabolic acid production, is reached when blood bicarbonate exceeds dialysate bicarbonate by 5 mmol/l.

Conclusions:

  • Bicarbonate CAPD solutions demonstrate a self-regulating feedback mechanism.
  • An equilibrium point is reached, maintaining stable acid-base status.
  • To achieve a target bicarbonatemia of 25 mmol/l, a CAPD solution bicarbonate concentration of approximately 30 mmol/l is recommended.