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In vivo cell tracking with bioluminescence imaging.
Jung Eun Kim1, Senthilkumar Kalimuthu1, Byeong-Cheol Ahn1
1Department of Nuclear Medicine, Kyungpook National University School of Medicine and Hospital, 50, Samduk 2-ga, Jung Gu, Daegu, Republic of Korea 700-721.
Nuclear Medicine and Molecular Imaging
|March 17, 2015
Summary
Molecular imaging uses bioluminescence to track cells in living organisms. This technique is crucial for developing and optimizing cell therapies by monitoring transplanted cells in preclinical models.
Area of Science:
- Biomedical research
- Molecular imaging
Background:
- Molecular imaging enables visualization and quantification of biological processes at cellular levels.
- In vivo cell tracking is vital for advancing cell therapies using transplanted cells.
- Bioluminescence imaging is commonly used for monitoring transplanted stem and immune cells.
Purpose of the Study:
- Provide an overview of bioluminescence.
- Discuss recent advancements in in vivo cell tracking using bioluminescence.
Main Methods:
- Review of bioluminescence principles.
- Analysis of current in vivo cell tracking applications.
Main Results:
- Bioluminescence imaging offers advantages for monitoring cell viability and therapeutic efficacy.
- Applications include tracking stem cells and immune cells in preclinical models.
Conclusions:
- Bioluminescence imaging is a powerful tool for in vivo cell tracking.
- It supports the development and optimization of cell-based therapies.
