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Cardiac output with CO2 rebreathing method in CAPD patients
S Bertoli1, D Scorza, A Genderini
1Renal Unit, L. Sacco Hospital, Milan, Italy.
Summary
Cardiac output (CO) was measured in patients on continuous ambulatory peritoneal dialysis (CAPD) using the CO2 rebreathing method. Results showed significantly lower CO, likely due to fluid redistribution, not heart failure.
Area of Science:
- Nephrology
- Cardiology
- Physiology
Background:
- Continuous ambulatory peritoneal dialysis (CAPD) is a common treatment for end-stage renal disease.
- Assessing cardiac function in CAPD patients is crucial for managing fluid balance and overall health.
- Previous studies have not fully elucidated the impact of CAPD on cardiac output.
Purpose of the Study:
- To evaluate cardiac output (CO) in CAPD patients using the CO2 rebreathing method.
- To compare CO measurements with a full versus an empty abdomen during CAPD.
- To investigate potential causes for observed changes in CO.
Main Methods:
- Fifteen CAPD patients (mean age 55 years, hemoglobin 10 g/dL) were studied.
- Cardiac output was measured using the CO2 rebreathing method (RCO2) and Fick's formula.
- Measurements were taken with both a full and an empty abdomen during CAPD.
Main Results:
- Mean CO was significantly lower (2.3 L/min) than theoretically calculated values (4.7 L/min) in CAPD patients.
- CO levels were similar regardless of whether the abdomen was full or empty.
- The reduction in CO was not attributed to left ventricular insufficiency.
Conclusions:
- CAPD patients exhibit a reduced cardiac output compared to predicted values.
- This reduction may be caused by fluid redistribution favoring the intracellular compartment.
- Observed increases in hematocrit and plasma proteins might be artifactual due to fluid shifts.