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Updated: Apr 16, 2026

3-D Imaging and Analysis of Neurons Infected In Vivo with Toxoplasma gondii
Published on: December 9, 2014
Toxoplasma gondii Exposure and the Risk of Schizophrenia
Shahram Khademvatan1, Jasem Saki2, Niloufar Khajeddin3
1Department of Parasitology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, IR Iran.
Background:
Schizophrenia is a major psychiatric disorder with a deeply destructive pathophysiology. There are evidences to indicate that infectious agents such as Toxoplasma gondii may play some roles in etiology of the disorder.
Objectives:
The current study aimed to determine the association between T. gondii exposure and the risk of schizophrenia.
Materials And Methods:
T. gondii IgG antibodies of 100 patients with schizophrenia as well as 200 healthy volunteers were assessed. The subjects also completed demographic questionnaires. Data was analyzed using the chi-square and Fisher exact tests.
Results:
The analyses confirmed the significant differences between healthy women and ones with schizophrenia (P = 0.001) as well as between males and females with schizophrenia (P = 0.009) in IgG positivity.
Conclusions:
The present study supported the contamination with T. gondii as a risk factor for schizophrenia just in women.
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