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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

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microRNA-based diagnostics and therapy in cardiovascular disease-Summing up the facts

Christian Schulte1, Tanja Zeller1

  • 11 Department of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, 20246 Hamburg, Germany ; 2 German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Lübeck/Kiel, Hamburg, Germany.

Cardiovascular Diagnosis and Therapy
|March 17, 2015
PubMed

Insights

Circulating microRNAs (miRNAs) show promise as biomarkers for diagnosing cardiovascular diseases like coronary artery disease (CAD) and myocardial infarction (MI). Research also explores their therapeutic potential, though standardization is needed.

Area of Science:

  • Cardiovascular Disease Research
  • Molecular Diagnostics
  • Biomarker Discovery

Background:

  • Circulating microRNAs (miRNAs) are investigated as disease-specific biomarkers in cardiovascular disease.
  • Numerous studies have evaluated their diagnostic and prognostic value in coronary artery disease (CAD) and myocardial infarction (MI).
  • miRNAs may complement existing biomarkers for diagnosing conditions like unstable angina pectoris (UAP).

Purpose of the Study:

  • To review current knowledge on circulating miRNAs in cardiovascular disease, focusing on CAD and MI.
  • To provide an overview of miRNAs as potential biomarkers for CAD and MI.
  • To explore the emerging role of miRNAs in cardiovascular therapeutics.

Main Methods:

  • Review of existing literature and studies on circulating miRNAs in cardiovascular disease.
  • Analysis of diagnostic and prognostic capabilities of miRNAs in CAD and MI.
  • Evaluation of miRNA-based therapeutic strategies in cardiovascular research.

Main Results:

  • Circulating miRNAs show potential as disease-specific biomarkers for CAD and MI.
  • Combinations of miRNAs (signatures) may offer improved predictive power over single miRNAs.
  • Early in vitro results suggest potential for miRNA-based cardiovascular therapeutics.

Conclusions:

  • Circulating miRNAs are promising biomarkers for diagnosing and stratifying risk in cardiovascular diseases like CAD and MI.
  • miRNA signatures may enhance diagnostic accuracy.
  • While therapeutic applications are emerging, standardization of methods for RNA isolation, detection, and normalization is crucial for clinical translation.
Keywords:
Artery diseasebiomarkercardiovascular diseasecirculatingcoronarydiagnosticmicroRNA (miRNA)myocardial infarction (MI)prognosticrisk stratification

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