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Updated: Apr 16, 2026
07:57
Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
Published on: December 8, 2011
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Candidiasis (vulvovaginal)
1Andalusian Agency for Health Technology Assessment (AETSA), Regional Ministry of Health and Social Welfare, Seville, Spain.
BMJ Clinical Evidence
|March 17, 2015
Summary
This systematic review evaluates drug and alternative treatments for vulvovaginal candidiasis in non-pregnant women. It found 23 studies assessing various interventions for symptomatic and asymptomatic cases.
Area of Science:
- Gynecology
- Infectious Diseases
- Pharmacology
Background:
- Vulvovaginal candidiasis is a common cause of vaginitis, with Candida albicans responsible for most cases.
- It is the second most frequent cause of vaginitis, following bacterial vaginosis.
Purpose of the Study:
- To systematically review the effects of drug treatments for acute vulvovaginal candidiasis in non-pregnant women.
- To evaluate alternative or complementary treatments for acute vulvovaginal candidiasis.
- To assess the effects of treating asymptomatic non-pregnant women with a positive candidiasis swab.
Main Methods:
- Systematic review of literature from Medline, Embase, and The Cochrane Library up to October 2013.
- Inclusion of harms alerts from regulatory agencies like the FDA and MHRA.
- GRADE evaluation of the quality of evidence for interventions.
Main Results:
- Twenty-three studies met the inclusion criteria for the review.
- Evidence quality for various interventions was assessed using the GRADE system.
Conclusions:
- The review presents information on the effectiveness and safety of diverse treatments.
- Interventions evaluated include drug treatments, alternative therapies, intravaginal preparations (nystatin, imidazoles, tea tree oil), oral fluconazole, oral itraconazole, and probiotics (Lactobacillus acidophilus).
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