Palladium-catalyzed highly efficient synthesis of functionalized indolizines via cross-coupling/cycloisomerization
Liangwei Zhang1, Xiangdong Li, Yuanhong Liu
1Center of Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang Road, Nanjing 210009, China. zhangdayong@cpu.edu.cn.
Abstract:
An efficient Pd-catalyzed cross-coupling/cycloisomerization of 3-(2-pyridyl) propargyl carbonates with organoboronic acids has been developed, which provides a straightforward route for the synthesis of 1,3-disubstituted indolizines with a wide variety of substituents. The mechanistic study indicates that the reaction proceeds via formation of an allenyl pyridine intermediate through palladium-catalyzed coupling reaction followed by cyclization.
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