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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
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Animal models of systemic sclerosis
Florence Morin, Niloufar Kavian, Frederic Batteux1
1Laboratoire d'Immunologie, INSERM U1016, Institut Cochin, Faculte de Medecine Paris Descartes et Laboratoire d'immunologie biologique, Hopital Cochin, 24 rue du faubourg St Jacques 75679 Paris cedex 14, France. frederic.batteux@cch.aphp.fr.
Current Pharmaceutical Design
|March 18, 2015
Summary
Systemic sclerosis (SSc) animal models aid research into its fibrosis and vasculopathy. These models are crucial for understanding SSc pathophysiology and developing new treatments for this incurable disease.
Area of Science:
- Rheumatology
- Immunology
- Pathophysiology
Background:
- Systemic sclerosis is a connective tissue disorder.
- It involves skin and organ fibrosis, vasculopathy, and immune issues.
Purpose of the Study:
- To review animal models of systemic sclerosis.
- To highlight their contributions to understanding SSc pathophysiology.
- To explore their role in developing new therapeutic strategies.
Main Methods:
- Review of existing literature on SSc animal models.
- Analysis of model contributions to SSc research.
Main Results:
- Various genetic and inducible animal models of SSc are available.
- These models have advanced understanding of SSc.
- Models are instrumental in exploring therapeutic avenues.
Conclusions:
- Animal models are essential tools for SSc research.
- Continued use of these models will drive progress in understanding and treating SSc.
